Study of mutagenic effects with predicted carcinogenicity of 4-((5-decylthio)-4-methyl-4-H-1,2,4-triazole-3-yl)methyl)morpholine for further research in order to create a new drug with antifungal activity

The development of effective and safe therapeutic agents using 1,2,4-triazole derivatives is gaining momentum in today’s conditions. value such drugs determined by the rapid prolonged biological action, which not accompanied abrupt changes homeostasis pronounced side effects, are characteristic most pharmacological synthetic origin. In context a limited range domestic antimicrobial antifungal veterinary on national pharmaceutical market, one directions for solving this problem search, study, research, with activity. aim work was to study mutagenic effects prediction carcinogenicity 4-((5-decylthio)-4-methyl-4-H-1,2,4-triazole-3-yl)methyl)morpholine prospect further creation new dosage forms treatment fungal pathologies skin. Materials methods. Staph used effect 4-((5-decylthio)-4-methyl-4-H-1,2,4-triazol-3-yl)methyl)morpholine vitro Staphylococcus aureus, strain 209, its UV-2, UV-3 mutants primary cell cultures. Accounting gene mutations microorganisms system metabolic activation (Ames test) carried out according method L. M. Fonshtein accordance requirements “Methodological recommendations assessing properties medicinal products” (Kyiv, 1996), supplemented methodology “Preclinical research (edited I. Ya. Kotsiumbas). Results. results studying activity model culture tumor ascetic cells showed that at concentrations 1.4 mg/ml, 0.8 0.3 0.015 mg/ml it led regression Ehrlich’s carcinoma C-37 sarcoma. experiments Nk/L y strain, same significantly slowed down growth. studies indicate cytogenetic thiophosfamide sarcolysin, suggests their body, as evidenced aberration chromosomes. When comparing equimolar concentrations, absence revealed. Conclusions. positive specific 4-((5-decylthio)-4-methyl-4-Н-1,2,4-triazole-3-yl)methyl)morpholine were obtained indicates expediency extensive experimental animal tumors. addition, these studies, no found doses predict carcinogenicity. Thus, can be concluded there effect.